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KMID : 0617320000090010158
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Journal of Pharmacetical Sceiences Ewha Womans University
2000 Volume.9 No. 1 p.158 ~ p.167
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7-(SUBSTITUTED-PHENYL)AMINO-5,8-ISOQUINOLINEDIONES
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Ryu, Chung-Kyu
Lee, In-Kyung/Jung, Sung-Hee/Kang, Hye-Young/Lee, Chong-Ock
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Abstract
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6-Chloro-7-(substituted-phenyl)amino-5,8-isoquinolinediones (3a-3u) and 7-(substituted-phenyl)amino-5,8-isoquinolinediones (4a-4d) were synthesized by nucleophilic substitution of 6,7-dichloro-5,8-isoquinolinedione (8) and 5,8-isoquinolinedione (9) with appropriate arylamines. The quinones 3a-3u and 4a-4d were evaluated for in vitro cytotoxic activities against five solid tumor cell lines such as A549, SK-OV-3, SK-MEL-2, XF498 and HCT-15. Among them, 3c, 3d, 3f and 3h exhibited potent activities against the cell lines HCT-15 and SK-MEL-2.
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